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NMN Supplement Reviews 2022

by: Adam Singfield
June 26, 2023

Nicotinamide mononucleotide (NMN) is a health supplement that can improve longevity and prevent diseases. But what is NMN exactly and how does it work? In this article, we’ll explore what NMN is, what it can do, and what the top NMN supplements on the market are.

What Is NMN?

Nicotinamide mononucleotide (NMN) is a molecule that occurs naturally in all living things. In our bodies, NMN is used to create nicotinamide adenine dinucleotide (NAD). There are other ways for the body to make NAD, like nicotinamide riboside (NR), which is a form of vitamin B3. However, NMN is the closest precursor to NAD.

Why Is NAD Important?

NAD is an essential coenzyme used by many proteins in the body. For example, sirtuins are a protein group that is vital to DNA repair. Anti-aging supplements often work to boost sirtuin productivity. NAD is also crucial for mitochondria which are the body’s generators, used in the energy production we need to live.

As we age, bodily functions begin to slow down, including the production of NAD. Reduced NAD levels in our bodies have been linked to age-associated physiological decline and age-related diseases. Taking NMN supplements can help the body maintain healthy NAD levels throughout our lives.

What Can NMN Do?

Animal trials on NMN supplementation have found interesting results. One study showed that giving aged mice water with NMN almost doubled their running endurance. Another study tested cognition in older mice and found that taking NMN had neuroprotective benefits, showing cognitive abilities closer to that of younger mice.

What Are The Benefits Of NMN?

Many talk about NMN as if it’s a magical cure-all or the fountain of youth. While these claims might be a little exaggerated, plenty of animal and human studies have shown many potential benefits to NMN supplementation.

Let’s look at what benefits NMN could provide:

Are There Side Effects To Taking NMN?

There are some anecdotal reports of NAD boosters causing side effects like nausea, stomach discomfort, and indigestion.

However, this has only been reported when taking very high doses. So far, human trials have found that NMN is not toxic or harmful when taken at the correct doses.

Clinical Trials On NMN Supplements

In Japan, a study of the effects of NMN on humans found no negative effects at doses of up to 500 mg. A different study that tested NMN’s effects on endurance in runners found no harmful effects at doses of up to 1,200 mg.

Another clinical trial tested doses of 300 mg, 600 mg, and 900 mg. The trial found no signs of increased toxicity, and NAD levels rose significantly in all test subjects.

Manufacturing Of NMN Supplements

The biggest risk comes from incorrect manufacturing processes. With the ever-increasing demand for NMN supplements, manufacturers all over the world have begun producing them.

Unfortunately, not all manufacturers are making them with safety and purity in mind. Many cut corners to maximize profits, claiming the same purity as pharmaceutical-grade NMN for a fraction of the price.

In the US, NMN is considered a dietary supplement, so manufacturers are not required to prove its product’s purity before selling it. Any impurities and byproducts in the finished product increases the possibility of a user experiencing side effects.

What To Do If You’re Experiencing Side Effects

If you’re new to taking NMN supplements, consider starting with a small dose of up to 250 mg for the first few weeks. If you are experiencing minor side effects, like stomach discomfort, consider lowering your dosage.

Remember that it’s always best to seek professional medical help if you’re experiencing side effects from any supplement.

Who Can Take NMN Supplements?

The more we age, the more our body’s processes begin slowing down. Thankfully, some studies have shown that taking NMN supplements could significantly slow the effects of aging.

One study found that, when NMN was given to mice throughout their lives, it greatly increased their lifespan. When NMN was given to aged mice, many beneficial effects were recorded, like improved cognitive function and increased energy levels.

It’s been suggested that NMN is ideally a preventative measure. So, it’s best to begin supplementation of NMN as a young adult. The recommended doses increase with age.

  • Younger adults: 250 mg per day could be sufficient as the body’s NAD production is at normal levels.
  • Middle-aged adults: A slightly higher dose of 500 mg per day is recommended, as NAD production has already begun slowing down, so more NMN is needed.
  • Older adults: A dose of 500 mg to 1000 mg has been suggested for this age group, as this is when NAD production is at its lowest.

How Do I Know If A Supplement Is Good-Quality?

Before purchasing any NMN supplement, it’s important to do your research. Energy-boosting and anti-aging supplements, such as NMN and NR, can work wonders and increase the quality of life. However, if it’s low quality, it may be less than pure or even contain harmful substances.

There are ways to make sure a supplement is what it claims to be. For example, check how companies manufacture their supplements or where it gets them from. Facilities that are cGMP-certified will have safeguards in place to ensure the higher purity and safety of their products. Another good indicator of the safety of a supplement is if it’s been used in clinical trials, medical studies, or has been endorsed by medical professionals.

Of course, before trying any new supplement, it’s always best to first consult your doctor. Also, be critical of any supplements that claim to be cure-alls without having the research to back them up.

Top 10 NMN Supplements On The Market

The extreme increase in the popularity of NMN supplements over the past few years has caused a flood of new NMN products in the market. Unfortunately, not all of these products are safe or healthy, and some could even be harmful.

However, many NMN products have been vetted by medical professionals or have been used in medical research and studies. Below, we’ve compiled a list of the safest and best NMN supplements or NAD boosters that you can trust.

NMN PowderPure NMN

The Best NMN supplement

Pure NMN was designed as a NMN supplement that could improve energy and boost athleticism. It could also sharpen cognitive skills and slow cognitive decline. Pure NMN manufacturers promise that it’s 100% vegan friendly and has no added preservatives. On top of being safe, Pure NMN supplements are third-party tested and shown to have 99% purity.

Pure NMN manufacturers make the product in an FDA-approved cGMP facility. cGMP is a regulation that assures proper design, control, and monitoring of manufacturing processes. So, you can trust that Pure NMN is safely manufactured in a controlled environment.

  • Content: 200 servings
  • Serving size: 2 scoops 
  • NMN dose: 500 mg

Renue By Science LIPO NMN

LIPO NMN is a powdered liposomal NMN created by Reneu By Science. Liposomal is a drug delivery system, where the active compound is contained inside small, fat-like particles, making it easier for the body to absorb. Renue By Science created this powdered liposomal as it may be more effective than the liquid form.

  • Content: 90 capsules 
  • Serving size: 1 capsule 
  • NMN dose: 250 mg 

UltraHealth PUR NMN™ Capsules

UltraHealth is another producer of NAD+ boosters. It offers two types of NMN supplements: PUR NMN™ and a more budget-friendly form.

PUR NMN™ contains lipid polymer-coated, extended-release capsules. These types of capsules are designed to resist breaking down too early in the stomach acids. This improves the bioavailability as it bypasses the stomach acid and is instead absorbed in the small intestine.

  • Content: 60 capsules
  • Serving size: 1 capsule
  • NMN dose: 250 mg

Renue By Science Fast Dissolve NMN™ Tablets

These Fast Dissolve NMN tablets are sublingual. A sublingual supplement is placed under the tongue and absorbed through the blood vessels located there. As NMN capsules can be broken down by stomach acids and rendered ineffectual, taking NMN sublingually means that it goes directly to the cells via the bloodstream.

These tablets contain a smaller NMN dosage than other NMN supplements. This is because, instead of increasing the dosage, Renue designed these sublingual tablets to improve their absorption capability.

  • Content: 240 capsules 
  • Serving size: 1 capsule
  • NMN dose: 125 mg

QuickSilver Scientific Liposomal NAD+ Platinum

QuickSilver Scientific focuses on creating potent supplements. Its NMN supplement, NAD+ Platinum, promotes healthy NAD levels in the body and helps in sirtuin activation. NAD+ Platnium is a liquid liposomal NMN, which increases absorption capabilities.

This product has a low NMN dose but, to make up for that, it has other NAD-boosting ingredients. That includes trimethylglycine (TMG), B vitamins (B2 and B12), resveratrol, and quercetin.

  • Content: 100ml
  • Serving size: 2.5ml
  • NMN dose: 50 mg

UltraHealth PUR™ 30c NMN Capsules

In addition to nicotinamide riboside (NR) supplements, UltraHealth also manufactures NMN supplements in an FDA-certified GMP facility. Its NMN products include three crystallization stages. This means that bioavailability is increased.

You can buy these capsules in bulk, so they’re very budget-friendly. They are sometimes purchased by clinics, doctors, and vitamin shops. Also, UltraHealth posts its complete Certificate of Analysis (CoA) and Protein Purity Analysis (HPLC).

  • Content: 300 capsules
  • Serving size: 1 capsule 
  • NMN dose: 250 mg

Renue By Science Fast Dissolve NMN Powder

This NMN product comes in powder form and is designed for sublingual (under the tongue) intake. Sublingual NMN supplements don’t go through the stomach so they bypass the stomach acid which could make it ineffective. The sublingual method of intake is considered a good way to feel the effects of NMN and see a boost in energy.

NMN supplementation can be quite expensive, but you can save a considerable amount by purchasing it in bulk. This product contains enough to last about a year.

  • Content: 400 servings
  • Serving size: 250 mg
  • NMN dose: 250 mg

Do Not Age NMN Powder

The best NMN supplements will be manufactured in a controlled environment to ensure purity and safety. However, once the product leaves the facility and goes through the delivery process, it could have degraded in quality. This is normally due to exposure to light, humidity, oxygen, or other environmental conditions.

Do Not Age (DNA) NMN powder ships safely and securely, so it guarantees the product’s potency at your doorstep. Do Not Age NMN supplements come in capsule or powder form and can be purchased in small to bulk amounts.

  • Content: 2000 servings
  • Serving size: 500 mg 
  • NMN dose: 500 mg

ProHealth Pro 300 NMN Capsules

The ProHealth NMN formula includes 150 mg of Uthever’s patented, stabilized NMN. ProHealth’s NMN capsules are tested in-house by Uthever. Then, they are batch-tested by ProHealth’s team to verify the NMN purity and stability.

The Pro 300 NMN capsules have been found to retain their purity stability for up to two years. This means it has an extended shelf-life compared to other products.

  • Content: 60 capsules
  • Serving size: 2 capsules 
  • NMN dose: 300 mg 

Renue By Science Pure NAD+ Micromist

This NAD-boosting product is designed to be used as a nasal spray. Similar to sublingual and liposomal NMN, this intranasal spray bypasses stomach acids, which could make NMN ineffective.

Intranasal NAD was designed to bypass the blood-brain barrier to deliver the beneficial molecules directly to the brain. It requires a low dose, so the risk of side effects is reduced.

  • Content: 30ml 
  • Serving size: 2 sprays 
  • NMN dose: 25mg

How Can I Increase NMN Naturally?

Taking NMN can result in an altered NAD metabolism that encourages protection against ailments such as metabolic disorders or skeletal muscle aging. However, you can also build up your NAD metabolism through more natural ways such as eating certain foods, exercising, and other activities that boost your NAD levels.

Let’s take a look at the various ways you can increase your NAD without supplementation.


Studies show that a varied diet is important for the optimal function of the human body. However, if you want to have a diet that specifically benefits your NAD metabolism, consider the following foods:

  • Whole grains: Eating whole grain foods reduces the number of calories retained while you digest your meal. This increases calorie loss and speeds up your metabolism. Consider buying food like brown rice, oats, quinoa, and whole wheat bread.
  • Oily fish: Oily fish are rich in omega-3 fatty acids. Some studies have shown that these can promote weight loss by lowering hunger sensations. Consider fish like salmon, sardines, mackerel, herring, and anchovies.
  • Fermented foods: The fermentation process can drastically alter the nutritional composition of food. Fermented food like kimchi, yogurt, sauerkraut, and pickles include natural probiotics that are good for your digestion – and the healthier you digest, the better your metabolism.


Studies show that exercise is an excellent way for your body to improve NAD metabolism and your health in general. Aerobic exercises such as running, swimming, and rowing improves cardiovascular health and boosts your metabolism. Weight training also helps you gain muscle mass which increases your metabolic rate and burns calories even when resting.

You don’t have to do long-distance running or Olympic weightlifting to reap the benefits of regular exercise. Even just 30-minute workouts that mix cardio with strength training three times a week can already do wonders for your NAD levels, metabolism, and health in general.

What People Say About NMN Supplements

Though clinical trials and medical studies only began recently, many health benefits have already been discovered through NMN supplementation. It’s been called the fountain of youth as it promotes DNA repair and increases sirtuin (the anti-aging molecule) activity.

Like any supplement, there will always be cases where supplementing NMN doesn’t provide the desired effect. But, so far, NMN supplement reviews have been largely positive.

Anecdotally, one American user suffering from chronic fatigue remarked on the drastically improved energy levels throughout the day with just 300 mg of the powdered NMN supplement. Another user in his 70s suffered from a degenerated lower back and problems with standing straight. This user claimed increased energy levels and better mental focus from just five weeks of taking 500 mg every night.

Some people who have taken NR supplements in the past have now switched to NMN. They claim that NMN gives them better energy levels, better cognitive focus, and more endurance than NR.

Final Thoughts

The potential health benefits of NMN have been talked about ceaselessly and range from increased longevity to improved energy levels, better mental health, and reduced risk of age-associated illnesses. While the results of clinical trials and medical studies have been promising, more research is needed, especially long-term, to fully ascertain all of its properties.

Before purchasing NMN supplements, be sure to do your research on the manufacturer and its safety and purity certificates. Another way to be sure a particular NMN supplement is pure and safe is by checking if it’s been endorsed by medical professionals or used in medical studies or trials.

All-in-all, research done so far with NMN shows exciting possibilities related to longevity, improved quality of life, and greater well-being.

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